24
May 2022 - 5:06 pm IST

Download Our Mobile App

States

SARS-CoV-2 may impair phagocytic immune-cell response to fungus

SARS-CoV-2 may impair phagocytic immune-cell response to fungus

Published:29 January 2022

SARS-CoV-2 may impair the phagocytic immune-cell response to the fungus, the main defence mechanism against mucormycosis, through viral-induced lymphopenia or the therapeutic use of corticosteroids.

Indore | SARS-CoV-2 may impair the phagocytic immune-cell response to the fungus, the main defense mechanism against mucormycosis, through viral-induced lymphopenia or the therapeutic use of corticosteroids. These findings were revealed following an indepty study carried out by the IIT Indore. The study was primarily carried out to understand post Covid-19 infection in terms of adjunct therapies and steroidal after-effects.
The findings of the study conducted by Dr. Hem Chandra Jha, the group leader of Infection Bioengineering at IIT Indore, along with his research scholars Charu Sonkar, interns Vaishnavi Hase, Durba Banerjee, Dr. Rajesh Kumar and Dr. Awanish Kumar from NIT, was recently published in the form of an article in Canadian Journal of Chemistry.
Inducibility and catastrophic effects of the virus can be found in a variety of organs, including lungs, kidneys, heart, skin, neurons, and others. The interaction of the SARS-CoV-2 virus and the host receptor causes cytokine storms in Covid-19 patients, which can lead to a variety of immunopathological consequences, including death, the study revealed. Covid-19 has affected millions of people around the world so far, but there is no effective treatment.
As per the study, SARS-CoV-2 may impair the phagocytic immune-cell response to the fungus, which is the main defense mechanism against mucormycosis, through viral-induced lymphopenia or the therapeutic use of corticosteroids. As a result, it is critical to have a thorough understanding of drugs and their devastating consequences. Patients who recovered from Covid-19 complications showed extensive clinical symptoms that were similar to those seen with previously circulating coronaviruses, said Dr Jha adding that in Covid-19 patients, the use of steroids as a treatment resulted in a variety of health issues and side effects. The study discussed the history of coronavirus epidemics, Post-Covid 19 Complications (PCC), and multiple organs damaged by it.
Dr. Jha said “Long-term use of corticosteroids is known to cause serious side effects. Covid-19's side effects, the receptors it targets, and the alternative drugs that can be used for Covid-19 have all been briefly discussed. Information on ARDS drugs and Covid-19 immunotherapies, that are still being tested, has also been included. 
The study includes information about antibodies that have been granted emergency use authorization. The facts that corticosteroids are an important treatment for Covid-19 have been considered. 
A thorough understanding of its receptors and side effects, on the other hand, would help provide accurate information about its use and when an alternative could be used.
As a result, extensive information on PCC, therapeutics under investigation, adjunct therapeutics for Covid-19 management, and other Covid-19 investigational immunotherapies has been provided.
The complications mentioned can affect a person in a single or multiple ways, and they can cause health problems for varying lengths of time, Dr Jha added.


വാർത്തകൾ

Links

Sign up for Newsletter



Copyright ©
All rights reserved by Metrovaartha.com

Tags

Download Apps

Google Play App Store
  • |
  • |
  • |
  •  

© Copyright Metro vaartha 2022 All rights reserved.

top